Animal Use Guidelines & Exceptions
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Anesthesia/Analgesia/Drugs
- Analgesia Guidelines
- Administration of Analgesics to Rodents
- Anesthesia, Surgery and Post-Procedural Recordkeeping
- Anesthetics, Analgesics and Tranquilizers in Lab Animals
- Avertin (2,2,2 Tribromoethanol)
- Calibration - Output Validation of Anesthetic Machine Vaporizers
- Hypothermia as Anesthesia for Neonatal Rodents
- Needle Re-Use
- Neuromuscular Blocking Agents in Animals
- Prevention, Assessment and Relief of Pain and Distress
- Use of Expired Drugs or Materials
- Use of Non-Pharmaceutical Grade Compounds in Animals
Euthanasia
- Euthanasia Guidelines
- Euthanasia for Amphibians, Reptiles, and Fish
- Humane Endpoints in Animal Care and Use Protocols
- Maintenance of Guillotines
- Perfusion as Euthanasia or as Non-survival Surgery
Housing/Husbandry
- Cage Space Guidelines
- Disaster/Emergency Planning
- Disaster/Emergency Plan Template for Animal Housing Sites
- Environmental Enrichment
- Housing and Husbandry Guidelines
- Investigator Managed Housing Area (IMHA) Oversight
- Maintenance of Animals on an Expired IACUC Protocol
- Social Housing
- Special Food or Fluid Provision Recordkeeping
- Transporting Animals
Surgery
- Anesthesia, Surgery and Post-Procedural Recordkeeping (sample forms at bottom of page)
- Anesthetics, Analgesics and Tranquilizers in Lab Animals
- Aquatic Survival Surgery Perioperative Considerations
- Avertin (2,2,2 Tribromoethanol)
- Multiple Surgical Procedures
- Surgery, Facility Requirements, Post-Procedural Care, Antibiotics
Other Common Procedures
- Administration of Cells, Tissue, and/or Bodily Fluids to Rodents
- Behavioral Equipment (Cleaning/Disinfecting)
- Blood Collection Guidelines
- Egg and Oocyte Harvesting in Xenopus laevis
- Food and Fluid Regulation
- Identification Methods Including Toe Clipping:
Toe-clipping: Toe-clipping must be described and justified in the Animal Care and Use Protocol and approved by the IACUC. Toe-clipping should be used only when no other individual identification method is feasible and only on altricial pre-weaning rodents (mice and rats, but not guinea pigs) after the toes are no longer webbed and before they reach 8 days of age. If possible, it is preferable to remove toes from a hind paw rather than a forepaw. In neonatal mice before 8 days of age it appears to have few adverse effects on behavior and well-being. When possible toe clipping and genotyping should be combined. Under all circumstances aseptic practices should be followed.
- Identification Labeling of Animals Outside of RAR
- Use of Non-Pharmaceutical Grade Compounds in Animals
- Physical Restraint
- Proper Sterilization of Materials Used in Animal Studies
- Restraint and Handling
- Rodent Tail Biopsy
- Tumor Endpoint Criteria
Protocols
- Amendment or Note to File
- Availability of IACUC Protocols
- Client Consent Form Help Aid
- Humane Endpoints in Animal Care and Use Protocols
- ILAR Experimental Design and Statistics
- Maintenance of Animals on an Expired IACUC Protocol
- Routes of Administration Guidelines
- Veterinarian Review Analgesia for Laboratory Animals Guidelines
- Veterinarian Review Blood Collection Guidelines
- Veterinarian Review Acceptable Euthanasia Guidelines
- Anesthesia Guidelines
Sample Anesthesia, Surgery and Post-Procedural Recordkeeping Forms
- Mouse/Rat/Non-Mammal Post-Operative Record
- Mouse/Rat/Non-Mammal Procedure Form
- Mouse/Rat/Non-Mammal Procedure Record
- USDA Species Procedure Surgery Record
- USDA Species Anesthesia Monitoring Record
- USDA Species Post Procedure Recovery and Care Record
- Anesthetic record for non-invasive procedures (e.g. inoculations, tail snips, imaging)
- Decapitation Log